ML systems continue to advance at a rapid pace and have the potential to revolutionize healthcare. Areas of medicine where large data sets have the greatest opportunity to benefit from this technology. Intensive care is one such area that generates large, multi-modal data and may see ML directly impact. Areas of clinical care that may be particularly suited to ML will be discussed, and what pain points exist for clinicians that can be solved by ML. A discussion of specific conditions that can be predicted by use of ML systems sill also be discussed.