Precision health can transform medicine over the next few decades. We can detect cancer several years earlier through simple blood tests, without invasive biopsies. We can tailor treatment plans based on mutations in a cancer cell. We can detect rare genetic disorders, assess disease risks, and intervene early. We can identify infectious pathogens early enough to prevent pandemics and avoid indiscriminate use of broad-spectrum antibiotics. Better drugs could be discovered by understanding the biological mechanisms of complex diseases such as Alzheimer’s. This talk will take a deeper look at computing applications that drive precision health and discuss systems challenges.